5-Fluorouracil Encapsulated Chitosan-Cellulose Fiber Bionanocomposites: Synthesis, Characterization and In Vitro Analysis towards Colorectal Cancer Cells

Cellulose and chitosan with remarkable biocompatibility sophisticated physiochemical characteristics can be a new dawn to the advanced drug nano-carriers in cancer treatment. This study aims synthesize layer-by-layer bionanocomposites from rice straw cellulose encapsulated 5-Fluorouracil (CS-CF/5FU BNCs) using ionic gelation method sodium tripolyphosphate (TPP) cross-linker. Data X-ray Fourier-transform infrared spectroscopy showed successful preparation of CS-CF/5FU BNCs. Based on images scanning electron microscopy, 48.73 ± 1.52 nm was estimated for an average size as spherical nanoparticles mostly coated rod-shaped reinforcement. indicated increase thermal stability after its encapsulation bionanocomposites. The efficiency found 86 2.75%. BNCs triggered higher release media simulating colorectal fluid pH 7.4 (76.82 1.29%) than gastric 1.2 (42.37 0.43%). In vitro cytotoxicity assays, fibers, towards CCD112 normal cells. Most promisingly, at 250 µg/mL concentration eliminated 56.42 0.41% HCT116 cells only 8.16 2.11% Therefore, this demonstrates that considered eco-friendly innovative nanodrug candidate potential